Cardiovascular Risk and the Endocannabinoid System
نویسندگان
چکیده
منابع مشابه
Cardiovascular Risk and the Endocannabinoid System
A number of studies and analyses have illustrated the increased rate of cardiovascular disease conferred by multiple risk factors. 1,2 Up to now, however, the primary focus for addressing cardiovascular risk has been the treatment of each risk factor separately (e.g., LDL cholesterol, hypertension, and diabetes). Major gaps in our overall understanding of the ways in which these individual risk...
متن کاملRole of the endocannabinoid system in regulating cardiovascular and metabolic risk factors.
Increased endocannabinoid (EC) system activity promotes excessive food intake and obesity in animals and humans. The EC system regulates food intake and hedonic reward through central mechanisms located within the hypothalamus and limbic forebrain. In rodent models, cannabinoid1 (CB1) receptor blockade reduces appetite and weight and prevents obesity and insulin resistance. The EC system also r...
متن کاملEndocannabinoid system and cardio-metabolic risk.
Recent research in bio-medical science has shown an integral role of endocannabinoid system (ECS) in determining cardio-metabolic risk of human body. The mechanism is mediated through binding of endocannabinoids at the CB1 receptors. The stimulation of CB1 receptor in the brain is believed to control and mediate the effects on appetite. In normal physiology, CB1 receptors activation is responsi...
متن کاملThe endocannabinoid system : a new therapeutic target for cardiovascular risk factor management
European guidelines on cardiovascular disease prevention in clinical practice have identified obesity and smoking as primary risk factors for cardiovascular disease, the increased prevalence of which underlines the need for new therapeutic targets. The endocannabinoid (EC) system is a physiological system, comprising the cannabinoid receptors, cannabinoid type 1 (CB1) and type 2 (CB2), and thei...
متن کاملEffect of blockage of the endocannabinoid system by CB(1) antagonism on cardiovascular risk.
The endocannabinoid system is a crucial player in the inflammatory processes underlying atherosclerosis. Recently, basic research studies and animal models have strongly supported the role of the endocannabinoid system not only in the regulation of classical cardiovascular risk factors (including lipid profile and glucose homeostasis), but also in the activation of immune cells and inflammatory...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Kansas Journal of Medicine
سال: 2008
ISSN: 1948-2035
DOI: 10.17161/kjm.v1i2.10762